доктор физико-математических наук, 03.00.02-биофизика, 2007; профессор по кафедре физики, 2010
молекулярная биофизика, термодинамика можмолекулярных взаимодействий, взаимодействия Лиганд-ДНК и лиганд-лиганд
CURRICULUM VITAE Mr. Maxim P. Evstigneev (Maksym Yevstygnyeyev by passport) INSTITUTIONAL: Professor, Department of Physics, AFFILIATION: Sevastopol National Technical University (SNTU), Universitetskaya, 33, Sevastopol, 99053, Ukraine; PERSONAL: Born: 22 December 1975 in Simferopol, Ukraine; Home address: Ostryakova str. 228, fl.13. Tel. +38-(0692)-673374 Language skills: English – fluent and Russian - native language. ACADEMIC QUALIFICATIONS AND CAREER 1998 BSc honours diploma in radioengineering 2001-2002 Assistant Professor, Department of Physics (SNTU) 2002 PhD in Biophysics 2002-2005 Lecturer in Physics and Biophysics 2005-2008 Reader of Physics and Biophysics 2004-2006 Scientific Secretary of Academic Board for awarding PhD degree in biophysics 2008-2009 Vice-Chairman of Academic Board for awarding PhD degree in biophysics 2005-present Head of Biophysical research group at SNTU 2005-present Member of Science-Technical Board of SNTU 2006-present Member of the American Chemical Society 2007 DrSci degree in Biophysics (03.00.02, phys.-math.sci) 2007-present Responsible Editor of SNTU Proceedings - Physics and Mathematics (a scientific journal) 2008-present Professor of Physics and Biophysics 2008-present Chairman of Sevastopol Division of Ukrainian Biophysical Society 2010-present Chairman of Academic Board for awarding PhD degree in biophysics (03.00.02 physico-mathematical sciences) AWARDS Govermental Prize from the Cabinet of Ministries of the Ukraine for prominent contribution to science (2001 and 2007) Stipend for young scientists from Cabinet of Ministries of the Ukraine (2003) Official title “A youngest DrSci all over the Ukraine in physico-mathematical sciences“ (2007) Stipend from Supreme Council of the Ukraine for prominent young scientists (2008) Govermental Prize from the President of the Ukraine for prominent contribution to science (2008) TEACHING EXPERIENCE Currently handled lecture courses and related tutorials: General Physics (part 1, part 2, part 3; each part covers one semester); Physics of Biopolymers; Biomolecular NMR spectroscopy; Molecular biophysics; Methods of biophysical experiment PhD SUPERVISION Under my supervision three PhD students received PhD degrees in Biophysics. Currently 4 PhD students are working under my supervision. AREA OF EXPERTISE Molecular biophysics, structural and thermodynamical analysis of Drug-Drug and Drug-DNA interactions using NMR, UV-Vis and Molecular modeling methods SCIENTIFIC GRANTS INTAS grant 97-31753, 1999-2002 Royal Society of Chemistry (UK) Fellowship to carry research work in NMR spectroscopy lab in Birkbeck college, University of London, UK (2003-2004) State-budget scientific project “Nucleotide” (0104U000568), 2003-2006 (Ukraine) State-budget scientific project “Ligand-3” (0107U001331), 2007-2009 (Ukraine) Royal Society of Chemistry (UK) grant for short-term research work in the University of Strathclyde, Glasgow (UK), 2008 Grant from Mexican Scientific Society (SER.No/103.5/07/2208- BUAP), 2008-2009 State-budget scientific project “Complex” (0110U001683), 2010-2012 (Ukraine) Personal grant from the President of the Ukraine for research work, 2009 Personal grant from European Biophysical Society for participation in European Biophysical congress, Genoa, Italy, 2009 PUBLICATIONS Prof Maxim P.Evstigneev has 200 scientific publications, among which 60 were published in peer-reviewed journals. Personal H index =8. Personal citation index =194. LIST OF RECENT PUBLICATIONS 1. Davies D.B., Evstigneev M.P., Veselkov D.A., Veselkov A.N. Hetero-association of anticancer antibiotics in aqueous solution: NMR and molecular mechanics analysis. Biophys.Chem. 2005. V.117. P.111-118. 2. Evstigneev M.P., Mukhina Yu.V., Davies D.B. Complexation of daunomycin with a DNA oligomer in the presence of an aromatic vitamin (B2) determined by NMR spectroscopy. Biophys.Chem. 2005. V.118. P.118-127. 3. Evstigneev M.P., Davies D.B., Veselkov A.N. Stochastic models (cooperative and non-cooperative) for NMR analysis of the hetero-association of aromatic molecules in aqueous solution. Chem. Phys. 2006. V.321. P.25-33. 4. Evstigneev M.P., Evstigneev V.P., Davies D.B. 1H NMR determination of the self-association of an acridine homodimer and its complexation with ethidium bromide in aqueous solution. J. Mol. Str. 2006. V.784. P.162-168. 5. Evstigneev M.P., Evstigneev V.P., Hernandez Santiago A.A., Davies D.B. Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution. Eur. J. Pharm. Sci. 2006. V.28. P.59-66. 6. Evstigneev M.P., Mukhina Yu.V., Davies D.B. 1H NMR study of the hetero-association of flavin-mononucleotide with mutagenic dyes: ethidium bromide and proflavine. Molecular Phys. 2006. V.104. P.647-654. 7. Evstigneev M.P., Rybakova K.A., Davies D.B. Complexation of norfloxacin with DNA in the presence of caffeine. Biophys.Chem. 2006. V.121. P.84-95. 8. Evstigneev M.P., Evstigneev V.P., Davies D.B. NMR investigation of the effect of caffeine on the hetero-association of an anticancer drug with a vitamin. Chem. Phys. Lett. 2006. V.432. P.248-251. 9. Evstigneev M.P., Khomich V.V., Davies D.B. Complexation of anthracycline drugs with DNA in the presence of caffeine. Eur. Biophys. J. 2006. V.36. P.1-11. 10. Bolotin P.A., Baranovsky S.F., Evstigneev M.P. Spectrophotometric investigation of the hetero-association of caffeine and thiazine dye in aqueous solution. Spectrochimica Acta Part A. 2006. V.64. P.693-697. 11. Kostjukov V.V., Pahomov V.I., Andrejuk D.D., Davies D.B., Evstigneev M.P. Investigation of the complexation of the anti-cancer drug novantrone with the hairpin structure of the deoxyheptanucleotide 5'-d(GpCpGpApApGpC). J.Mol.Str. 2007. V.843. P.78-86. 12. Kostjukov V.V., Lantushenko A.O., Davies D.B., Evstigneev M.P. On the origin of the decrease in stability of the DNA hairpin d(GCGAAGC) on complexation with aromatic drugs. Biophys.Chem. 2007. V.129. P.56-59. 13. Ovchinnikov D.V., Baranovsky S.F., Rozvadovska A.O., Rogova O.V., Veselkov K.A., Ermolaev D.V., Parkes H., Davies D.B., Evstigneev M.P. Structural basis for the binding affinity of a homologous series of synthetic phenoxazone drugs with DNA: NMR and molecular mechanics analysis. J. Biomol. Str. Dyn. 2007. V.24, N5. P.443-454. 14. Evstigneev M.P., Evstigneev V.P., Davies D.B. A method for analysis of multicomponent systems of interacting aromatic molecules in solution. J. Chem. Phys. 2007. V.127. Art No.15154. 15. Evstigneev M.P., Lantushenko A.O., Evstigneev V.P., Mykhina Yu.V., Davies D.B. Quantitation of the molecular mechanisms of biological synergism in a mixture of DNA-acting aromatic drugs. Biophys.Chem. 2008. V.132. P.148-158. 16. Andrejuk D.D., Hernandez Santiago A.A., Khomich V.V., Voronov V.K., Davies D.B., Evstigneev M.P. Structural and thermodynamic analysis of the hetero-association of theophylline with aromatic drug molecules. J. Mol. Str. 2008. V.889. P.229-236. 17. Kostjukov V.V., Khomytova N.M., Davies D.B., Evstigneev M.P. Electrostatic contribution to the energy of binding of aromatic ligands with DNA. Biopolymers. 2008. V.89, N8. P.680-690. 18. Kostjukov V.V., Khomytova N.M., Evstigneev M.P. Partition of thermodynamic energies of Drug-DNA complexation. Biopolymers. 2009. V.91. P.773-790. 19. Hernandez Santiago A.A., Andrejuk D.D., Cervantes Tavera A.M., Davies D.B., Evstigneev M.P. Complexation of biologically active aromatic compounds with DNA in the presence of theophylline. J. Biol. Phys. 2009. V.35. P.115-126. 20. Beshnova D.A., Lantushenko A.O., Davies D.B., Evstigneev M.P. Profiles of equilibrium constants for self-association of aromatic molecules. J. Chem. Phys. 2009. V.130, N16. Art.No.165105. 21. Hernandez Santiago A.A., Rosas Castilla S., Morales Rodriguez A., Aleskerova E.A., Lantushenko A.O., Kostjukov V.V., Davies. D.B., Evstigneev M.P. Relation between structure and enthalpy for stacking interactions of aromatic molecules. Molecular Phys. 2010. V.108, No.15. P.1941-1947. 22. Beshnova D.A., Lantushenko A.O., Evstigneev M.P. Does the ligand-biopolymer equilibrium binding constant depend on the number of bound ligands? // Biopolymers. 2010. V.93, N11. P.932-935. 23. Evstigneev M.P., Parkinson J.A., Lantushenko A.O., Kostjukov V.V., Pahomov V.I. Hexamer oligonucleotide topology and assembly under solution phase NMR and theoretical modeling scrutiny // Biopolymers. 2010. V.93, N12. P.1023-1038. 24. Evstigneev M.P. DNA-binding aromatic drug molecules: Physico-chemical interactions and their biological roles // Lambert Academic Publishing, 2010, 96 p, ISBN 978-3-8433-5389-2.